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Results for ANK2


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ANK2

Description
ankyrin 2
Aliases
ANK-2, CFAP87, FAP87, LQT4, brank-2

Gene Identifiers

Entrez ID
287
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_001127493.2; NM_001148.6; NM_001354225.1; NM_001354228.1; NM_001354230.1; NM_001354231.1; NM_001354232.1; NM_001354235.1; NM_001354236.1; NM_001354237.1; NM_001354239.1; NM_001354240.1; NM_001354241.1; NM_001354242.1; NM_001354243.1; NM_001354244.1; NM_001354245.1; NM_001354246.1; NM_001354249.1; NM_001354252.1; NM_001354253.1; NM_001354254.1; NM_001354255.1; NM_001354256.1; NM_001354257.1; NM_001354258.1; NM_001354260.1; NM_001354261.1; NM_001354262.1; NM_001354264.1; NM_001354265.1; NM_001354266.1; NM_001354267.1; NM_001354268.1; NM_001354269.1; NM_001354270.1; NM_001354271.1; NM_001354272.1; NM_001354273.1; NM_001354274.1; NM_001354275.1; NM_001354276.1; NM_001354277.1; NM_001354278.1; NM_001354279.1; NM_001354280.1; NM_001354281.1; NM_001354282.1; NM_020977.4; XM_005262945.3; XM_017008067.1; XM_017008069.1; XM_017008071.2; XM_017008072.2; XM_017008073.2; XM_017008074.2; XM_017008075.2; XM_017008076.2; XM_017008077.2; XM_017008078.2; XM_017008080.2; XM_024454016.1; XM_024454017.1; XM_024454018.1; XM_024454019.1; XM_024454020.1; XM_024454021.1; XM_024454022.1; XM_024454023.1

Protein Identifiers

RefSeq (protein)
NP_001120965.1; NP_001139.3; NP_001341154.1; NP_001341157.1; NP_001341159.1; NP_001341160.1; NP_001341161.1; NP_001341164.1; NP_001341165.1; NP_001341166.1; NP_001341168.1; NP_001341169.1; NP_001341170.1; NP_001341171.1; NP_001341172.1; NP_001341173.1; NP_001341174.1; NP_001341175.1; NP_001341178.1; NP_001341181.1; NP_001341182.1; NP_001341183.1; NP_001341184.1; NP_001341185.1; NP_001341186.1; NP_001341187.1; NP_001341189.1; NP_001341190.1; NP_001341191.1; NP_001341193.1; NP_001341194.1; NP_001341195.1; NP_001341196.1; NP_001341197.1; NP_001341198.1; NP_001341199.1; NP_001341200.1; NP_001341201.1; NP_001341202.1; NP_001341203.1; NP_001341204.1; NP_001341205.1; NP_001341206.1; NP_001341207.1; NP_001341208.1; NP_001341209.1; NP_001341210.1; NP_001341211.1; NP_066187.2; XP_005263002.1; XP_016863556.1; XP_016863558.1; XP_016863560.1; XP_016863561.1; XP_016863562.1; XP_016863563.1; XP_016863564.1; XP_016863565.1; XP_016863566.1; XP_016863567.1; XP_016863569.1; XP_024309784.1; XP_024309785.1; XP_024309786.1; XP_024309787.1; XP_024309788.1; XP_024309789.1; XP_024309790.1; XP_024309791.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
106410
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver
  • Damaged in 218/7921 TCGA samples
  • Damaged in 69/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 54 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 4 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials