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Results for CANX

Expand for information on CANX

CANX

Description

calnexin

Aliases

CNX, IP90, P90

Gene Identifiers

Entrez ID

821

Ensembl Gene ID

ENSG00000127022

mRNA Identifiers

RefSeq (mRNA)

NM_001024649.2; NM_001363993.1; NM_001363994.1; NM_001363995.1; NM_001363996.1; NM_001363997.1; NM_001363998.1; NM_001363999.1; NM_001364000.1; NM_001364001.1; NM_001746.4; XM_011534664.2; XM_011534665.3

Protein Identifiers

RefSeq (protein)

NP_001019820.1; NP_001350922.1; NP_001350923.1; NP_001350924.1; NP_001350925.1; NP_001350926.1; NP_001350927.1; NP_001350928.1; NP_001350929.1; NP_001350930.1; NP_001737.1; XP_011532966.1; XP_011532967.1

Uniprot ID

P27824; P27824; P27824

Ensembl protein ID

ENSP00000391646.2; ENSP00000247461.4; ENSP00000424063.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

114217

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Candidate cancer driver
Damaged in 68/7921 TCGA samples
Damaged in 13/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
43/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1019/1019 in CCLE
943/970 in CLP
675/675 in GenenTech

Protein Expression in Tissues

45/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 733 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 98 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Equal damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Not essential in 1122 cell lines

Gene Function

4/6 level 1 KEGG pathways
3/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers