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Results for DLG2


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DLG2

Description
discs large MAGUK scaffold protein 2
Aliases
PPP1R58, PSD-93, PSD93, chapsyn-110

Gene Identifiers

Entrez ID
1740
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_001142699.2; NM_001142700.2; NM_001142702.2; NM_001206769.2; NM_001300983.1; NM_001351274.2; NM_001351275.2; NM_001351276.2; NM_001364.3; NM_001377966.1; NM_001377967.1; NM_001377968.1; NM_001377970.1; NM_001377971.1; NM_001377972.1; NM_001377973.1; NM_001377974.1; NM_001377975.1; NM_001377976.1; NM_001377977.1; NM_001377978.1; NM_001377979.1; NM_001377980.1; NM_001377981.1; NM_001377982.1; NM_001377983.1; XM_005273810.4; XM_011544778.3; XM_011544780.3; XM_011544782.2; XM_017017254.2; XM_017017255.2; XM_017017256.2; XM_017017257.2; XM_017017258.1; XM_017017261.2; XM_017017262.1; XM_017017263.1; XM_017017264.2; XM_017017265.2; XM_017017267.1; XM_017017268.1; XM_017017269.1; XM_017017270.1; XM_017017271.2; XM_017017273.2; XM_017017276.1; XM_017017277.1; XM_017017279.1; XM_017017280.2; XM_017017281.2; XM_017017284.1; XM_017017285.1; XM_017017286.2; XM_017017287.1; XM_017017288.1; XM_017017289.1; XM_017017290.1; XM_024448378.1; XM_024448379.1

Protein Identifiers

RefSeq (protein)
NP_001136171.1; NP_001136172.1; NP_001136174.1; NP_001193698.1; NP_001287912.1; NP_001338203.1; NP_001338204.1; NP_001338205.1; NP_001355.2; NP_001364895.1; NP_001364896.1; NP_001364897.1; NP_001364899.1; NP_001364900.1; NP_001364901.1; NP_001364902.1; NP_001364903.1; NP_001364904.1; NP_001364905.1; NP_001364906.1; NP_001364907.1; NP_001364908.1; NP_001364909.1; NP_001364910.1; NP_001364911.1; NP_001364912.1; XP_005273867.1; XP_011543080.1; XP_011543082.1; XP_011543084.1; XP_016872743.1; XP_016872744.1; XP_016872745.1; XP_016872746.1; XP_016872747.1; XP_016872750.1; XP_016872751.1; XP_016872752.1; XP_016872753.1; XP_016872754.1; XP_016872756.1; XP_016872757.1; XP_016872758.1; XP_016872759.1; XP_016872760.1; XP_016872762.1; XP_016872765.1; XP_016872766.1; XP_016872768.1; XP_016872769.1; XP_016872770.1; XP_016872773.1; XP_016872774.1; XP_016872775.1; XP_016872776.1; XP_016872777.1; XP_016872778.1; XP_016872779.1; XP_024304146.1; XP_024304147.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
603583
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver
  • Damaged in 127/7921 TCGA samples
  • Damaged in 30/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 56 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 2 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1064 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials