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Results for EPB41


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EPB41

Description
erythrocyte membrane protein band 4.1
Aliases
4.1R, EL1, HE

Gene Identifiers

Entrez ID
2035
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_001166005.1; NM_001166006.1; NM_001166007.2; NM_001376013.1; NM_001376014.1; NM_001376015.1; NM_001376016.1; NM_001376017.1; NM_001376018.1; NM_001376019.1; NM_001376020.1; NM_001376021.1; NM_001376022.1; NM_001376023.1; NM_001376024.1; NM_001376025.1; NM_001376026.1; NM_001376027.1; NM_001376028.1; NM_004437.4; NM_203342.2; NM_203343.3; XM_005245753.1; XM_005245757.1; XM_005245760.1; XM_005245763.1; XM_005245764.1; XM_005245768.1; XM_005245769.1; XM_005245770.1; XM_005245774.1; XM_006710434.1; XM_006710439.1; XM_011540956.1; XM_011540957.1; XM_011540958.1; XM_011540959.1; XM_011540960.1; XM_011540961.1; XM_011540962.1; XM_011540964.1; XM_011540965.3; XM_017000581.1; XM_017000582.1; XM_017000583.1; XM_017000584.2; XM_017000585.2; XM_017000589.1; XM_017000590.1; XM_017000592.1; XM_017000593.1; XM_017000594.1; XM_017000595.1; XM_017000596.1; XM_017000597.1; XM_024453880.1

Protein Identifiers

RefSeq (protein)
NP_001159477.1; NP_001159478.1; NP_001159479.1; NP_001362942.1; NP_001362943.1; NP_001362944.1; NP_001362945.1; NP_001362946.1; NP_001362947.1; NP_001362948.1; NP_001362949.1; NP_001362950.1; NP_001362951.1; NP_001362952.1; NP_001362953.1; NP_001362954.1; NP_001362955.1; NP_001362956.1; NP_001362957.1; NP_004428.1; NP_976217.1; NP_976218.1; XP_005245810.1; XP_005245814.1; XP_005245817.1; XP_005245820.1; XP_005245821.1; XP_005245825.1; XP_005245826.1; XP_005245827.1; XP_005245831.1; XP_006710497.1; XP_006710502.1; XP_011539258.1; XP_011539259.1; XP_011539260.1; XP_011539261.1; XP_011539262.1; XP_011539263.1; XP_011539264.1; XP_011539266.1; XP_011539267.1; XP_016856070.1; XP_016856071.1; XP_016856072.1; XP_016856073.1; XP_016856074.1; XP_016856078.1; XP_016856079.1; XP_016856081.1; XP_016856082.1; XP_016856083.1; XP_016856084.1; XP_016856085.1; XP_016856086.1; XP_024309648.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
130500
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver
  • Damaged in 61/7921 TCGA samples
  • Damaged in 22/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 166 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 51 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1122 cell lines

Gene Function

  • Not present in KEGG
  • 1/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials