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Results for EPHA2


Expand for information on EPHA2

EPHA2

Description
EPH receptor A2
Aliases
ARCC2, CTPA, CTPP1, CTRCT6, ECK

Gene Identifiers

Entrez ID
1969
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
176946
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver, TIME driver
  • Damaged in 137/7921 TCGA samples
  • Damaged in 38/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 180 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 57 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 2 drugs
  • Response/resistance in 1 cell lines
  • Response/resistance in 0 trials