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FTO
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FTO
Description
FTO alpha-ketoglutarate dependent dioxygenase
Aliases
ALKBH9, BMIQ14, GDFD
Gene Identifiers
mRNA Identifiers
RefSeq (mRNA)
NM_001080432.3; NM_001363891.1; NM_001363894.1; NM_001363896.1; NM_001363897.1; NM_001363898.1; NM_001363899.1; NM_001363900.1; NM_001363901.1; NM_001363903.1; NM_001363905.1; NM_001363988.1; XM_011523314.3; XM_011523315.3; XM_011523316.3; XM_017023654.2; XM_017023655.2; XM_017023656.2; XM_017023657.2; XM_017023658.2; XM_024450437.1
Protein Identifiers
RefSeq (protein)
NP_001073901.1; NP_001350820.1; NP_001350823.1; NP_001350825.1; NP_001350826.1; NP_001350827.1; NP_001350828.1; NP_001350829.1; NP_001350830.1; NP_001350832.1; NP_001350834.1; NP_001350917.1; XP_011521616.1; XP_011521617.1; XP_011521618.1; XP_016879143.1; XP_016879144.1; XP_016879145.1; XP_016879146.1; XP_016879147.1; XP_024306205.1
Uniprot ID
Ensembl protein ID
Protein Architecture
SMART
Disease Mapping
Druggability
- Candidate cancer driver
- Damaged in 56/7921 TCGA samples
- Damaged in 12/1291 cell lines
- Fewer loss of function mutations
- Equal damaging SNVs/indels
- Fewer structural variants