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Results for KCNH5


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KCNH5

Description
potassium voltage-gated channel subfamily H member 5
Aliases
EAG2, H-EAG2, Kv10.2, hEAG2

Gene Identifiers

Entrez ID
27133
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
605716
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver
  • Damaged in 112/7921 TCGA samples
  • Damaged in 30/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • One duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 7 protein(s)
  • Part of zero complexes

miRNA Interactions

  • Interacts with 10 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1122 cell lines

Gene Function

  • Not present in KEGG
  • 1/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials