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Results for PCM1


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PCM1

Description
pericentriolar material 1
Aliases
PTC4, RET/PCM-1

Gene Identifiers

Entrez ID
5108
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_001315507.2; NM_001315508.1; NM_001352632.2; NM_001352633.2; NM_001352634.2; NM_001352635.2; NM_001352636.2; NM_001352637.2; NM_001352638.2; NM_001352639.2; NM_001352640.2; NM_001352641.2; NM_001352642.2; NM_001352643.2; NM_001352644.2; NM_001352645.2; NM_001352646.2; NM_001352647.2; NM_001352648.2; NM_001352649.2; NM_001352650.2; NM_001352651.2; NM_001352652.2; NM_001352653.2; NM_001352654.2; NM_001352655.2; NM_001352656.2; NM_001352657.2; NM_001352658.2; NM_001352659.1; NM_001352660.1; NM_006197.4; XM_006716336.3; XM_006716340.3; XM_011544528.2; XM_011544529.2; XM_011544530.2; XM_011544532.2; XM_011544534.2; XM_017013472.1; XM_017013473.1; XM_017013478.1; XM_017013480.1; XM_017013481.1; XM_017013486.1; XM_017013489.1; XM_017013490.2; XM_017013491.1; XM_017013493.1; XM_017013496.2; XM_017013501.1; XM_024447167.1; XM_024447168.1; XM_024447169.1; XM_024447170.1; XM_024447171.1

Protein Identifiers

RefSeq (protein)
NP_001302436.2; NP_001302437.1; NP_001339561.2; NP_001339562.2; NP_001339563.2; NP_001339564.2; NP_001339565.2; NP_001339566.2; NP_001339567.2; NP_001339568.2; NP_001339569.2; NP_001339570.2; NP_001339571.2; NP_001339572.2; NP_001339573.2; NP_001339574.2; NP_001339575.2; NP_001339576.2; NP_001339577.2; NP_001339578.2; NP_001339579.2; NP_001339580.2; NP_001339581.2; NP_001339582.2; NP_001339583.2; NP_001339584.2; NP_001339585.2; NP_001339586.2; NP_001339587.2; NP_001339588.1; NP_001339589.1; NP_006188.4; XP_006716399.1; XP_006716403.1; XP_011542830.1; XP_011542831.1; XP_011542832.1; XP_011542834.1; XP_011542836.1; XP_016868961.1; XP_016868962.1; XP_016868967.1; XP_016868969.1; XP_016868970.1; XP_016868975.1; XP_016868978.1; XP_016868979.1; XP_016868980.1; XP_016868982.1; XP_016868985.1; XP_016868990.1; XP_024302935.1; XP_024302936.1; XP_024302937.1; XP_024302938.1; XP_024302939.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
600299
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver
  • Damaged in 90/7921 TCGA samples
  • Damaged in 21/1291 cell lines

Evolutionary Conservation

  • Metazoans

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 323 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 3 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 13/1095 cell lines

Gene Function

  • Not present in KEGG
  • 2/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials