Home Query results

Results for PICALM


Expand for information on PICALM

PICALM

Description
phosphatidylinositol binding clathrin assembly protein
Aliases
CALM, CLTH, LAP

Gene Identifiers

Entrez ID
Ensembl Gene ID

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Candidate cancer driver
  • Damaged in 126/7921 TCGA samples
  • Damaged in 17/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 155 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 20 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 4/1095 cell lines

Gene Function

  • Not present in KEGG
  • 1/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials