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Results for PLCH2

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PLCH2

Description

phospholipase C eta 2

Aliases

PLC-L4, PLC-eta2, PLCL4, PLCeta2

Gene Identifiers

Entrez ID

9651

Ensembl Gene ID

ENSG00000149527

mRNA Identifiers

RefSeq (mRNA)

NM_001303012.2; NM_001303013.1; NM_014638.4; XM_017002870.1; XM_017002872.1; XM_017002873.1; XM_017002874.1; XM_024451058.1; XM_024451059.1; XM_024451060.1; XM_024451061.1; XM_024451062.1; XM_024451063.1; XM_024451064.1

Protein Identifiers

RefSeq (protein)

NP_001289941.1; NP_001289942.1; NP_055453.2; XP_016858359.1; XP_016858361.1; XP_016858362.1; XP_016858363.1; XP_024306826.1; XP_024306827.1; XP_024306828.1; XP_024306829.1; XP_024306830.1; XP_024306831.1; XP_024306832.1

Uniprot ID

O75038; O75038; O75038

Ensembl protein ID

ENSP00000397289.1; ENSP00000367747.3

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

612836

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Candidate cancer driver
Damaged in 64/7921 TCGA samples
Damaged in 18/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

22/30 tissues in GTEx
26/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

166/1019 in CCLE
939/970 in CLP
91/675 in GenenTech

Protein Expression in Tissues

12/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 4 protein(s)
Part of zero complexes

miRNA Interactions

Interacts with 2 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Equal damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Not essential in 1060 cell lines

Gene Function

1/6 level 1 KEGG pathways
1/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers