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Results for POLR2D


Expand for information on POLR2D

POLR2D

Description
RNA polymerase II subunit D
Aliases
HSRBP4, HSRPB4, RBP4, RPB16, RPB4

Gene Identifiers

Entrez ID
5433
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
606017
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver
  • Damaged in 22/7921 TCGA samples
  • Damaged in 3/1291 cell lines

Evolutionary Conservation

  • Eukaryotes

Gene Duplication

  • One duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 78 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 83 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1024/1082 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials