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Results for PTK2


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PTK2

Description
protein tyrosine kinase 2
Aliases
FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK

Gene Identifiers

Entrez ID
5747
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_001199649.2; NM_001316342.2; NM_001352694.2; NM_001352695.2; NM_001352696.2; NM_001352697.2; NM_001352698.2; NM_001352699.2; NM_001352700.2; NM_001352701.2; NM_001352702.2; NM_001352703.2; NM_001352704.2; NM_001352705.2; NM_001352706.2; NM_001352707.2; NM_001352708.2; NM_001352709.2; NM_001352710.2; NM_001352711.2; NM_001352712.2; NM_001352713.2; NM_001352714.2; NM_001352715.2; NM_001352716.2; NM_001352717.2; NM_001352718.2; NM_001352719.2; NM_001352720.2; NM_001352721.2; NM_001352722.2; NM_001352723.2; NM_001352724.2; NM_001352725.2; NM_001352726.2; NM_001352727.2; NM_001352728.2; NM_001352729.2; NM_001352730.2; NM_001352731.2; NM_001352732.2; NM_001352733.2; NM_001352734.2; NM_001352735.2; NM_001352736.2; NM_001352737.2; NM_001352738.2; NM_001352739.2; NM_001352740.2; NM_001352741.2; NM_001352742.2; NM_001352743.2; NM_001352744.2; NM_001352745.2; NM_001352746.2; NM_001352747.2; NM_001352748.2; NM_001352749.2; NM_001352750.2; NM_001352751.2; NM_001352752.2; NM_005607.5; NM_153831.4; XM_017013653.2; XM_017013654.2; XM_017013656.2; XM_017013657.2; XM_017013664.2; XM_017013666.1; XM_017013669.2; XM_017013684.2; XM_017013688.2; XM_024447199.1; XM_024447200.1; XM_024447201.1; XM_024447202.1; XM_024447203.1; XM_024447204.1; XM_024447205.1; XM_024447206.1; XM_024447207.1; XM_024447208.1; XM_024447209.1; XM_024447210.1; XM_024447211.1; XM_024447212.1

Protein Identifiers

RefSeq (protein)
NP_001186578.1; NP_001303271.1; NP_001339623.1; NP_001339624.1; NP_001339625.1; NP_001339626.1; NP_001339627.1; NP_001339628.1; NP_001339629.1; NP_001339630.1; NP_001339631.1; NP_001339632.1; NP_001339633.1; NP_001339634.1; NP_001339635.1; NP_001339636.1; NP_001339637.1; NP_001339638.1; NP_001339639.1; NP_001339640.1; NP_001339641.1; NP_001339642.1; NP_001339643.1; NP_001339644.1; NP_001339645.1; NP_001339646.1; NP_001339647.1; NP_001339648.1; NP_001339649.1; NP_001339650.1; NP_001339651.1; NP_001339652.1; NP_001339653.1; NP_001339654.1; NP_001339655.1; NP_001339656.1; NP_001339657.1; NP_001339658.1; NP_001339659.1; NP_001339660.1; NP_001339661.1; NP_001339662.1; NP_001339663.1; NP_001339664.1; NP_001339665.1; NP_001339666.1; NP_001339667.1; NP_001339668.1; NP_001339669.1; NP_001339670.1; NP_001339671.1; NP_001339672.1; NP_001339673.1; NP_001339674.1; NP_001339675.1; NP_001339676.1; NP_001339677.1; NP_001339678.1; NP_001339679.1; NP_001339680.1; NP_001339681.1; NP_005598.3; NP_722560.1; XP_016869142.1; XP_016869143.1; XP_016869145.1; XP_016869146.1; XP_016869153.1; XP_016869155.1; XP_016869158.1; XP_016869173.1; XP_016869177.1; XP_024302967.1; XP_024302968.1; XP_024302969.1; XP_024302970.1; XP_024302971.1; XP_024302972.1; XP_024302973.1; XP_024302974.1; XP_024302975.1; XP_024302976.1; XP_024302977.1; XP_024302978.1; XP_024302979.1; XP_024302980.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
600758
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver, TIME driver
  • Damaged in 671/7921 TCGA samples
  • Damaged in 25/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 184 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 9 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 152/1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials