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Results for SMC2

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SMC2

Description

structural maintenance of chromosomes 2

Aliases

CAP-E, CAPE, SMC-2L1, SMC2

Gene Identifiers

Entrez ID

10592

Ensembl Gene ID

ENSG00000136824

mRNA Identifiers

RefSeq (mRNA)

NM_001042550.2; NM_001042551.2; NM_001265602.1; NM_006444.3; XM_006716933.3; XM_011518148.2; XM_011518149.3; XM_011518150.2; XM_011518151.2; XM_011518152.2; XM_011518153.1; XM_017014206.1; XM_017014207.1; XM_017014208.1; XM_017014209.1; XM_017014210.2; XM_017014211.2; XM_017014212.1; XM_024447383.1

Protein Identifiers

RefSeq (protein)

NP_001036015.1; NP_001036016.1; NP_001252531.1; NP_006435.2; XP_006716996.1; XP_011516450.1; XP_011516451.1; XP_011516452.1; XP_011516453.1; XP_011516454.1; XP_011516455.1; XP_016869695.1; XP_016869696.1; XP_016869697.1; XP_016869698.1; XP_016869699.1; XP_016869700.1; XP_016869701.1; XP_024303151.1

Uniprot ID

A0A024R158; Q6IPS5; Q05BV1; B3KMB1; O95347; O95347; A0A024R158; Q05BV1; A8K984; B7ZLZ7; A0A024R158; O95347; A0A024R158; Q7Z2X1; Q05D74; Q05BV1; O95347; A0A024R158; O95347; O95347; A0A024R158; A0A024R158; O95347; O95347; A0A024R158; O95347; O95347; A0A024R158; A0A024R158; O95347

Ensembl protein ID

ENSP00000363919.3; ENSP00000286398.7; ENSP00000363925.3

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

605576

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Candidate cancer driver
Damaged in 75/7921 TCGA samples
Damaged in 25/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

29/30 tissues in GTEx
41/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1018/1019 in CCLE
935/970 in CLP
675/675 in GenenTech

Protein Expression in Tissues

39/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 142 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 25 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Equal damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 982/1115 cell lines

Gene Function

Not present in KEGG
1/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers