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Results for ST3GAL6

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ST3GAL6

Description

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Aliases

SIAT10, ST3GALVI

Gene Identifiers

Entrez ID

10402

Ensembl Gene ID

ENSG00000064225

mRNA Identifiers

RefSeq (mRNA)

NM_001271142.1; NM_001271145.1; NM_001271146.1; NM_001271147.1; NM_001271148.1; NM_001323352.1; NM_001323353.1; NM_001323358.1; NM_001323359.1; NM_001323360.1; NM_001323362.1; NM_001323363.1; NM_001323364.1; NM_001323365.1; NM_001323366.1; NM_001323367.1; NM_001323368.1; NM_006100.3

Protein Identifiers

RefSeq (protein)

NP_001258071.1; NP_001258074.1; NP_001258075.1; NP_001258076.1; NP_001258077.1; NP_001310281.1; NP_001310282.1; NP_001310287.1; NP_001310288.1; NP_001310289.1; NP_001310291.1; NP_001310292.1; NP_001310293.1; NP_001310294.1; NP_001310295.1; NP_001310296.1; NP_001310297.1; NP_006091.1

Uniprot ID

A0A087WXB8; Q9Y274; Q9Y274; Q9Y274; Q9Y274; Q9Y274; Q9Y274; Q9Y274

Ensembl protein ID

ENSP00000480884.1; ENSP00000417376.1; ENSP00000265261.6; ENSP00000377717.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

607156

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Candidate cancer driver
Damaged in 18/7921 TCGA samples
Damaged in 7/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
39/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

397/1019 in CCLE
941/970 in CLP
304/675 in GenenTech

Protein Expression in Tissues

44/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 22 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 7 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Equal damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 1/1064 cell lines

Gene Function

1/6 level 1 KEGG pathways
3/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers