Gene query results

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Results for TG

Expand for information on TG

Description

thyroglobulin

Aliases

AITD3N, TG

Gene Identifiers

Entrez ID

7038

Ensembl Gene ID

ENSG00000042832

mRNA Identifiers

RefSeq (mRNA)

NM_003235.5; XM_005251038.4; XM_005251040.4; XM_005251042.4; XM_006716622.3; XM_017013793.1; XM_017013794.1; XM_017013795.1; XM_017013796.1; XM_017013797.1; XM_017013798.1; XM_017013799.1; XM_017013800.1

Protein Identifiers

RefSeq (protein)

NP_003226.4; XP_005251095.1; XP_005251097.1; XP_005251099.1; XP_006716685.1; XP_016869282.1; XP_016869283.1; XP_016869284.1; XP_016869285.1; XP_016869286.1; XP_016869287.1; XP_016869288.1; XP_016869289.1

Uniprot ID

P01266; P01266

Ensembl protein ID

ENSP00000220616.4

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

188450

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Candidate cancer driver
Damaged in 144/7921 TCGA samples
Damaged in 48/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

8/30 tissues in GTEx
16/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

21/1019 in CCLE
954/970 in CLP
13/675 in GenenTech

Protein Expression in Tissues

1/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 10 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 24 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Equal damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 1/1122 cell lines

Gene Function

2/6 level 1 KEGG pathways
Not present in Reactome

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers