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TNF

Description
tumor necrosis factor
Aliases
DIF-alpha, TNFA, TNFSF2, TNLG1F, TNF

Gene Identifiers

Entrez ID
7124
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
191160
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver
  • Damaged in 5/7921 TCGA samples
  • Damaged in 6/1291 cell lines

Evolutionary Conservation

  • Vertebrates

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 323 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 10 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1119 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 7 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials